|Boswellia serrata (Frankincense)|
The boswellic acids are the major active constituents. These compounds have been found to inhibit a number of pro-inflammatory and cell signaling pathway chemicals and cytokines involved in chemotaxis, increased vascular permeability and brochoconstriction. They also are inhibitors of matrix metalloproteinases(MMPs), which play a major role in cartilage destruction and tumor invasion and metastasis. In addition, they inhibit human leukocyte elastase (HLE), which has been implicated in the development of asthma, cystic fibrosis, chronic bronchitis & emphysema.
Studies have demonstrated the efficacy of Boswellia extract in asthma, chronic bronchitis, arthritis, rheumatoid arthritis, chronic colitis, ulcerative colitis, Crohn's disease and cancer chemo-prevention.
|Citrus reticulata (mandarin orange)|
Is a source of the bioflavonoids of the class polymethoxylated flavones. Included in this class are nobiletin, tangeretin & others.
Recent studies on the polymethoxylated flavone components of orange peel have demonstrated a host of activities with preventive and therapeutic potential relevant to a number of conditions. These conditions include: arthritis, inhibition of enzymatic cartilage destruction, asthma and COPD, inflammatory conditions (acute and chronic), hyperlipidemia (lowers serum lipids), high cholesterol and LDL, hyperglycemia (glucose homeostasis), insulin resistance, heart disease, varicose veins, capillary permeability, Alzheimer's disease and Hepatitis C.
Flavonoids have been referred to as "nature's biological response modifiers" because of strong experimental evidence of their ability to modify the body's reaction to allergens, viruses, carcinogens, microbes & inflammation.
Like the curcuminoids, flavonoids have matrix metalloproteinase (MMP) inhibitory activity, which helps relieve chronic inflammation and inhibit cartilage destruction and tumor invasion(metastasis).
|Curcuma longa (Turmeric)|
Has been the subject of much research and evaluation of its bioactive properties. The main bioactive constituents of Curcuma are curcuminoids.
Research has demonstrated anti-inflammatory, anti-oxidant, anti-viral, chemo preventive (early pre-cancer) and anti-cancer activities, as well as molecular biological action such as matrix-metalloproteinase(MMP) inhibitory activity. MMPs are responsible for cartilage destruction and are involved in perpetuating the chronic cycle of inflammation found to underlie many incurable chronic inflammatory diseases.
Curcumin's anti-inflammatory action is exerted at several sites along the inflammatory pathway and is the result of several diverse mechanisms acting in concert (see studies section).
Curcumin has demonstrated efficacy in relieving symptoms of arthritis as well as inhibiting the joint destructive activity of MMPs on cartilage.
Curcumin has demonstrated chemo preventive activity against colon, duodenal, fore-stomach, mammary, leukemic, pancreatic, and oral and skin cancers.
Curcumin has been shown to support cardiovascular health and most recently, has been investigated and found to be efficacious in suppressing the symptoms of Type II diabetes, multiple sclerosis and Alzheimer's.
|Camelia sinensis (green tea)|
Has been the subject of much scientific research recently. Originally this research concentrated on the high anti-oxidant activity present, and its health benefits were attributed to this feature. Anti-oxidants neutralize free radicals that damage cells and genetic material (DNA & RNA) and are involved in the aging process. Green tea's anti-oxidant activity is the result of the constituents known as polyphenols. The primary polyphenols are catechins and gallocatechins. Further research demonstrated that these compounds also possess anti-inflammatory, anti-cytokine and matrix metalloproteinase (MMP) inhibitory activity. These activities (inflammation, free radical damage, increased cytokine and MMP activity) are instrumental in the processes underlying an array of conditions including: heart disease, atherosclerosis, arthritis, cancer, cartilage destruction, asthma, colitis (IBD/Crohn's), insulin resistance, diabetes and chronic inflammatory diseases (rheumatoid arthritis, multiple sclerosis, pulmonary fibrosis). Studies in these areas have shown the catechins and gallocatechins to be beneficial in these conditions. In addition, green tea has been shown to reduce elevated cholesterol levels, while increasing HDL (good cholesterol) levels.